The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

The Hippo pathway, a cascade of protein kinases that inhibits the oncogenic transcriptional coactivators YAP and TAZ, was discovered in Drosophila as a major determinant of organ size in development. Known modes of regulation involve surface proteins that mediate cell‐cell contact or determine epithelial cell polarity which, in a tissue‐specific manner, use intracellular complexes containing FERM domain and actin‐binding proteins to modulate the kinase activities or directly sequester YAP. Unexpectedly, recent work demonstrates that GPCRs, especially those signaling through Galpha12/13 such (...) as the protease activated receptor PAR1, cause potent YAP dephosphorylation and activation. This response requires active RhoA GTPase and increased assembly of filamentous (F‐)actin. Morever, cell architectures that promote F‐actin assembly per se also activate YAP by kinase‐dependent and independent mechanisms. These findings unveil the ability of GPCRs to activate the YAP oncogene through a newly recognized signaling function of the actin cytoskeleton, likely to be especially important for normal and cancerous stem cells. (shrink)

It will be settled out for the open problem of designing an r-order finite-time state observer for reaction-diffusion genetic regulatory networks with time-varying delays. By assuming the Dirichlet boundary conditions, aiming to estimate the mRNA and protein concentrations via available network measurements. Firstly, sufficient F-T stability conditions for the filtering error system have been investigated via constructing an appropriate Lyapunov–Krasovskii functional and using several integral inequalities and convex technique simultaneously. These conditions are delay-dependent and reaction-diffusion-dependent and can be checked by (...) MATLAB toolbox. Furthermore, a method is proposed to design an r-order F-T state observer, and the explicit expressions of observer gains are given. Finally, a numerical example is presented to illustrate the effectiveness of the proposed method. (shrink)

I feel very honoured to be able to attend this international conference entitled 'Criticism and the Growth of Knowledge: 20 Years After' dedicated to the memory of Imre Lakatos. I am grateful to Prof. Kostas Gavroglou, Secretary of the Organizing Committee, for his invitation. Today I want to use this chance to give a brief account of the dissemination of Lakatos's doctrines in China. Although Lakatos was already famous in Western academic circles of philosophy of science as early as the (...) 1960s because of his distinguished contributions to both the philosophy of mathematics and the philosophy of science, yet his doctrines began their dissemination in China only after the beginning of the 1980s.1 In 1979, when I worked in the Institute of Philosophy, Chinese Academy of Social Sciences (CASS), I started Ziran Kexue Zhexue Wenti Congkan (Journal for Philosophical Problems in Natural Sciences), and held the post of editor-in-chief. The second issue of 1980 (appearing on June 25, 1980) published the following papers by Lakatos. (1) 'The Methodology of Scientific Research Programmes' (translated passages by Qui Renzong, read and revised by Fan Dainian from Philosophical Papers, Vol. 1, Cambridge University Press, 1978, pp. 47-52,68-72). (2) 'A Renaissance of Empiricism in the Recent Philosophy of Mathematics?' (Translated by Lin Xiashui, read and revised by Qiu Renzong from British Journal for the Philosophy of Science, 27, pp. 201-23, 1976) The second part of this paper was published in the third issue of the same journal (appearing on September 25, 1976). These are probably the first translations of Lakatos' papers to appear in China. (shrink)

This chapter contains sections titled: Pluralistic Ignorance Modal Operator Epistemology Agents and Inquiry Methods Multimodal Systems Knowledge Transmissibility Knowledge Transmissibility and Public Announcement Knowledge Transmissibility and Pluralistic Ignorance References.

Addressing both collegiate and professional sports, the updated edition of Fair Play: The Ethics of Sport explores the ethical presuppositions of competitive athletics and their connection both to ethical theory and to concrete moral dilemmas that arise in actual athletic competition. This fourth edition has been updated with new examples, including a discussion of Spygate by the New England Patriots and recent discoveries on the use of performance enhancing drugs by top athletes. Two additional authors, Cesar R. Torres and Peter (...) F. Hager, bring to this edition a discussion of the moral issues involved in youth sports and the ethics of being a fan, as well as a fresh perspective on the theories of broad internalism and the quest for excellence. Furthermore, major criticisms of broad internalism by philosophers William J. Morgan and Scott Kretchmar add a new dimension to the discussion on the moral foundations of winning. (shrink)

In this review of Fan Ruiping’s book, I am concerned first of all about how representative his account of Confucianism/Ruism is in relationship to the multiform traditions associated with that teaching through more than two thousand years of its existence. Fan emphasizes pre-imperial forms of Confucian traditions, but neglects many alternatives from later sources. Secondly, his account of “familism” lends itself to questions related to the problem of revenge that is associated with traditional Confucianism. This raises further ethical doubts about (...) the effectiveness of his reconstructed Confucianism within contemporary Chinese society. Finally, his “familism” appears to focus on extended family structures, but whether this is suitable and relevant for the structures of modern family transformations in mainland China is questioned. (shrink)

The notorious ‘measurement problem’ has been roving around quantum mechanics for nearly a century since its inception, and has given rise to a variety of ‘interpretations’ of quantum mechanics, which are meant to evade it. We argue that no less than six problems need to be distinguished, and that several of them classify as different types of problems. One of them is what traditionally is called ‘the measurement problem’. Another of them has nothing to do with measurements but is a (...) profound metaphysical problem. We also analyse critically Maudlin’s (Topoi 14:7–15, 1995) well-known statement of ‘three measurements problems’, and the clash of the views of Brown (Found Phys 16:857–870, 1986) and Stein (Maximal of an impossibility theorem concerning quantum measurement. In: R. S. Cohen et al. (Eds.), Potentiality, entanglement and passion-at-a-distance, 1997) on one of the six measurement problems. Finally, we summarise a solution to one measurement problem which has been largely ignored but tacitly if not explicitly acknowledged. (shrink)

First published in 1982. Routledge is an imprint of Taylor & Francis, an informa company.

This article provides an introduction to the articles in this theme issue. This collection examines epistemological, ontological, moral and political questions in medicine in light of the philosophical ideas of Charles Taylor. A synthesis of Taylor's relevant work is presented. Taylor has argued for a conception of the human sciences that regards human life as meaningful–deriving meaning from surrounding horizons of significance. An overview of the interdisciplinary articles in this issue is presented. This collection advances our thinking in the philosophy (...) of medicine as well as the philosophy of Charles Taylor. (shrink)

We maximally extend the quantum‐mechanical results of Muller and Saunders ( 2008 ) establishing the ‘weak discernibility’ of an arbitrary number of similar fermions in finite‐dimensional Hilbert spaces. This confutes the currently dominant view that ( A ) the quantum‐mechanical description of similar particles conflicts with Leibniz’s Principle of the Identity of Indiscernibles (PII); and that ( B ) the only way to save PII is by adopting some heavy metaphysical notion such as Scotusian haecceitas or Adamsian primitive thisness. We (...) take sides with Muller and Saunders ( 2008 ) against this currently dominant view, which has been expounded and defended by many. *Received July 2008; revised May 2009. †To contact the authors, please write to: F. A. Muller, Faculty of Philosophy, Erasmus University Rotterdam, Burg. Oudlaan 50, H5–16, 3062 PA Rotterdam, The Netherlands; e‐mail: [email protected] , and Institute for the History and Foundations of Science, Utrecht University, Budapestlaan 6, IGG–3.08, 3584 CD Utrecht, The Netherlands; e‐mail: [email protected] . M. P. Seevinck, Institute for the History and Foundations of Science, Utrecht University, Budapestlaan 6, IGG–3.08, 3584 CD Utrecht, The Netherlands; e‐mail: [email protected]. (shrink)

One of the reasons provided for the shift away from an ontology for physical reality of material objects & properties towards one of physical structures & relations (Ontological Structural Realism: OntSR) is that the quantum-mechanical description of composite physical systems of similar elementary particles entails they are indiscernible. As material objects, they 'whither away', and when they wither away, structures emerge in their stead. We inquire into the question whether recent results establishing the weak discernibility of elementary particles pose a (...) threat for this quantum-mechanical reason for OntSR, because precisely their newly discovered discernibility prevents them from 'whithering away'. We argue there is a straightforward manner to consider the recent results as a reason in favour of OntSR rather than against it. (shrink)

We discuss the case against Factorism, which is the standard assumption in quantum mechanics that the labels of the $$\otimes$$ ⊗ -factor Hilbert-spaces in direct-product Hilbert-spaces of composite physical systems of similar particles refer to particles, either directly or descriptively. We distinguish different versions of Factorism and argue for their truth or falsehood. In particular, by introducing the concepts of snapshot Hilbert-space and Schrödinger-movie, we demonstrate that there are Hilbert-spaces and $$\otimes$$ ⊗ -factorisations where the labels do refer, even descriptively, (...) to similar particles, which renders them probabilistically absolutely discernible. (shrink)

Researchers have identified the phenomena of moral distress through many studies in Western countries. This research reports the first study of moral distress in Iran. Because of the differences in cultural values and nursing education, nurses working in intensive care units may experience moral distress differently than reported in previous studies. This research used a qualitative method involving semistructured and in-depth interviews of a purposive sample of 31 (28 clinical nurses and 3 nurse educators) individuals to identify the types of (...) moral distress among clinical nurses and nurse educators working in 12 cities in Iran. A content analysis of the data produced four themes to describe the nurses’ moral distress. The four themes were as follows: (a) institutional barriers and constraints; (b) communication problems; (c) futile actions, malpractice, and medical/care errors; (d) inappropriate responsibilities, resources, and competencies. The results demonstrate that moral distress for intensive care unit nurses is different and that the nursing leaders must reduce moral distress among nursing in intensive care. (shrink)

This article is a translation into english of a lecture given by paneth in 1931. The content of the work is described by the section titles: (1) the need for epistemological clarification of the fundamental concepts of chemistry, (2) the concept of substance in chemistry, (3) the epistemological standpoint of the ancient atomists, (4) the epistemological position of the concept of element introduced by lavoisier, (5) the double meaning of the chemical concept of element: 'basic substance' and 'simple substance', And (...) (6) the double meaning of other chemical concepts. Sections (4)-(6) are published in the following number of this journal. (staff). (shrink)

Hayek's substantial contribution to theoretical psychology has been addressed in the work of Thomas Szasz, Gerald Edelman, and Joaquin Fuster.

I begin by criticizing an elaboration of an argument in this journal due to Hawley , who argued that, where Leibniz’s Principle of the Identity of Indiscernibles faces counterexamples, invoking relations to save PII fails. I argue that insufficient attention has been paid to a particular distinction. I proceed by demonstrating that in most putative counterexamples to PII , the so-called Discerning Defence trumps the Summing Defence of PII. The general kind of objects that do the discerning in all cases (...) form a category that has received little if any attention in metaphysics. This category of objects lies between indiscernibles and individuals and is called relationals: objects that can be discerned by means of relations only and not by properties. Remarkably, relationals turn out to populate the universe. (shrink)

With a new foreword by Paul Kelly 'I regard Hayek's work as a new opening of the most fundamental debate in the field of political philosophy' - Sir Karl Popper 'This promises to be the crowning work of a scholar who has devoted a lifetime to thinking about society and its values. The entire work must surely amount to an immense contribution to social and legal philosophy' - Philosophical Studies Law, Legislation and Liberty is Hayek's major statement of political philosophy (...) and one of the most ambitious yet subtle defences of a free market society ever written. A robust defence of individual liberty, it is also crucial for understanding Hayek's influential views concerning the role of the state: far from being an innocent bystander, he argues that the state has an important role to play in defending the norms and practices of an ordered and free society. His arguments had a profound influence on the policies of Thatcher in the 1980s and resonate today in visions of the 'Big Society'. First published in three separate volumes, this Routledge Classics edition makes one of his most important books available in a single volume. Essential reading for understanding the background to the recent world economic turmoil and financial crisis, it also foreshadows the subsequent heated debate about regulation and political governance if such disasters are to be avoided in the future. (shrink)

We inquire into the question whether the Aristotelean or classical \emph{ideal} of science has been realised by the Model Revolution, initiated at Stanford University during the 1950ies and spread all around the world of philosophy of science --- \emph{salute} P.\ Suppes. The guiding principle of the Model Revolution is: \emph{a scientific theory is a set of structures in the domain of discourse of axiomatic set-theory}, characterised by a set-theoretical predicate. We expound some critical reflections on the Model Revolution; the conclusions (...) will be that the philosophical problem of what a \emph{scientific theory} is has \emph{not} been solved yet --- \emph{pace} P.\ Suppes. While reflecting critically on the Model Revolution, we also explore a proposal of how to complete the Revolution and briefly address the intertwined subject of \emph{scientific representation}, which has come to occupy center stage in philosophy of science over the past decade. (shrink)

This article is a translation into english of a lecture given by paneth in 1931. The content of the work is described by the section titles: (1) the need for epistemological clarification of the fundamental concepts of chemistry, (2) the concept of substance in chemistry, (3) the epistemological standpoint of the ancient atomists, (4) the epistemological position of the concept of element introduced by lavoisier, (5) the double meaning of the chemical concept of element: 'basic substance' and 'simple substance', And (...) (6) the double meaning of other chemical concepts. Sections (4)-(6) are published in the following number of this journal. (staff). (shrink)

The aim of this article is to analyse the contemporary ‘futility discourse’ from a constructivist perspective. I will argue that bioethics discourse typically disregards the con text from which controversies emerge and the processes that inform and constrain such discourse. Constructivists have argued that scientific knowledge is expressive of the dominant paradigm within which a scientific community is working. I will outline an analysis of ‘medical futility’ as a construction of biomedical and bioethical communities (and their respective paradigms). I will (...) trace the emergence and utilization of futility in the literature. My analysis of the context (i.e. the historical circumstances, the particular actors involved) within which the futility discourse emerged suggests that medical futility was constructed, in part, as a means of enhancing physician domination of a context wherein medical authority was threatened. The actors in this debate express widely divergent frameworks of ‘the good’, arguing from distinctive representations of moral agency. At times, this controversy has been argued from incommensurate moral horizons wherein the discussants debate incomparable problems. This discussion is related to a study of the ‘practice’ of futility in the clinical context. Further studies on the construction of bioethical problems are a necessary condition for supporting the truth claims of bioethical arguments. (shrink)

This article is a translation into english of a lecture given by paneth in 1931. The content of the work is described by the section titles: (1) the need for epistemological clarification of the fundamental concepts of chemistry, (2) the concept of substance in chemistry, (3) the epistemological standpoint of the ancient atomists, (4) the epistemological position of the concept of element introduced by lavoisier, (5) the double meaning of the chemical concept of element: 'basic substance' and 'simple substance', And (...) (6) the double meaning of other chemical concepts. Sections (4)-(6) are published in the following number of this journal. (staff). (shrink)

In a recent issue of this journal, M. Frisch claims to have proven that classical electrodynamics is an inconsistent physical theory. We argue that he has applied classical electrodynamics inconsistently. Frisch also claims that all other classical theories of electromagnetic phenomena, when consistent and in some sense an approximation of classical electrodynamics, are haunted by “serious conceptual problems” that defy resolution. We argue that this claim is based on a partisan if not misleading presentation of theoretical research in classical electrodynamics.

We inquire into the question whether the Aristotelean or classical \emph{ideal} of science has been realised by the Model Revolution, initiated at Stanford University during the 1950ies and spread all around the world of philosophy of science --- \emph{salute} P.\ Suppes. The guiding principle of the Model Revolution is: \emph{a scientific theory is a set of structures in the domain of discourse of axiomatic set-theory}, characterised by a set-theoretical predicate. We expound some critical reflections on the Model Revolution; the conclusions (...) will be that the philosophical problem of what a \emph{scientific theory} is has \emph{not} been solved yet --- \emph{pace} P.\ Suppes. While reflecting critically on the Model Revolution, we also explore a proposal of how to complete the Revolution and briefly address the intertwined subject of \emph{scientific representation}, which has come to occupy center stage in philosophy of science over the past decade. (shrink)

The author endeavours to show two things: first, that Schrödingers (and Eckarts) demonstration in March (September) 1926 of the equivalence of matrix mechanics, as created by Heisenberg, Born, Jordan and Dirac in 1925, and wave mechanics, as created by Schrödinger in 1926, is not foolproof; and second, that it could not have been foolproof, because at the time matrix mechanics and wave mechanics were neither mathematically nor empirically equivalent. That they were is the Equivalence Myth. In order to make the (...) theories equivalent and to prove this, one has to leave the historical scene of 1926 and wait until 1932, when von Neumann finished his magisterial edifice. During the period 1926–1932 the original families of mathematical structures of matrix mechanics and of wave mechanics were stretched, parts were chopped off and novel structures were added. To Procrustean places we go, where we can demonstrate the mathematical, empirical and ontological equivalence of ‘the final versions of’ matrix mechanics and wave mechanics. -/- The present paper claims to be a comprehensive analysis of one of the pivotal papers in the history of quantum mechanics: Schrödingers equivalence paper. Since the analysis is performed from the perspective of Suppes structural view (‘semantic view’) of physical theories, the present paper can be regarded not only as a morsel of the internal history of quantum mechanics, but also as a morsel of applied philosophy of science. The paper is self-contained and presupposes only basic knowledge of quantum mechanics. For reasons of length, the paper is published in two parts; Part I appeared in the previous issue of this journal. Section 1 contains, besides an introduction, also the papers five claims and a preview of the arguments supporting these claims; so Part I, Section 1 may serve as a summary of the paper for those readers who are not interested in the detailed arguments. (shrink)